Jet fuel toxicology, Toksykologia i Epidemiologia
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TOXICOLOGY
JET FUEL
TOXICOLOGY
Edited by
Mark L. Witten
Errol Zeiger
Glenn D. Ritchie
Boca Raton London New York
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Taylor & Francis Group, an
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JET FUEL
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Library of Congress Cataloging‑in‑Publication Data
Jet fuel toxicology / editors, Mark L. Witten, Errol Zeiger, Glenn David Ritchie.
p. cm.
Includes bibliographical references and index.
ISBN 978-1-4200-8020-9 (hardcover : alk. paper)
1. Jet planes--Fuel--Toxicology. I. Witten, Mark L. (Mark Lee), 1953- II. Zeiger, Errol.
III. Ritchie, Glenn David. IV. Title.
RA1242.H87J48 2011
615.9’5--dc22
2010021868
Visit the Taylor & Francis Web site at
and the CRC Press Web site at
Dedication
Dr. Mark Witten
would like to dedicate this book to his wife, Christine, and son,
Brandon. Thank you for being supportive as I have lived the life of a research scien-
tist for the past 30 years! My fondest wish will soon be fulilled when my son pursues
a medical career as well.
Dr. Glenn Ritchie
would like to dedicate this book to three very bright scientists,
without whom my knowledge of the scientiic method and my concern for the wel-
fare of others would be far less:
To Dr. Donald R. Meyer, the former Director of the Physiological Psychology
Department, Department of Psychology, The Ohio State University
(Columbus, Ohio)
To his wife and Laboratory Supervisor, Dr. Patricia Meyer
To Commander John Rossi III, Ph.D., former Director of the Neurobehavioral
Toxicology Laboratory at the U.S. Navy Detachment-Toxicology at Wright-
Patterson Air Force Base (Dayton, Ohio).
These three individuals taught me to believe nothing until valid laboratory data con-
irmed it to be so.
Dr. Errol Zeiger
would like to dedicate this book to his wife, Mardi, for her constant
support.
Contents
Chapter
Air Force-Related Jet Fuel Toxicology Research (1991–2010) ............ 1
Walter J. Kozumbo
Chapter
Jet Fuel Composition .......................................................................... 21
Tim Edwards
Chapter
The Toxicity and Underlying Mechanism of Jet Propulsion
Fuel-8 on the Respiratory System ...................................................... 27
Simon S. Wong and Mark L. Witten
Chapter
Neurotoxicological and Neurobehavioral Effects from
Exposure to Jet Fuels.......................................................................... 43
Glenn D. Ritchie
Chapter
Differential Protein Expression Following JP-8 Jet Fuel
Exposure............................................................................................. 73
Frank A. Witzmann and Mark L. Witten
Chapter
Immune Modulation by Dermal Exposure to Jet Fuel..................... 103
Gerardo Ramos and Stephen E. Ullrich
Chapter
Absorption, Penetration, and Cutaneous Toxicity of Jet Fuels
and Hydrocarbon Components......................................................... 119
James E. Riviere, Alfred O. Inman, and Nancy Monteiro-Riviere
Chapter
Methods of Assessing Skin Irritation and Sensitization of
Jet Fuels ............................................................................................ 135
R. Jayachandra Babu, Ram Patlolla, and Mandip Singh
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